At Novalix, we are able to efficiently integrate the experience of discovery chemists with the constraints of process chemistry.
The rapid implementation of new chemical processes, elimination of bottlenecks, and development of shorter synthetic routes are key drivers in reducing capital investment and lowering the overall cost of goods. By streamlining workflows and improving efficiency, these strategies enable faster time-to-market and more agile project execution. Our chemists are deeply experienced in designing and developing synthetic routes that are not only safe and economically viable but also robust, reproducible, and scalable. This ensures that each process is optimized for long-term success, from early discovery through to commercial manufacturing.
Paper Route Design
Objectives: identify original and scalable synthetic routes.
Activities: our team delivers a detailed report that maps and evaluates possible synthetic routes to the target molecule. This report provides a guide for the next steps during the development of production processes. The creativity of our PhD chemists is complemented by the latest AI-based retrosynthetic tools.
Deliverables: exhaustive report including evaluation of relevant routes.
Route Scouting
Objectives: determine feasibility of routes or unlock key steps.
Activities: laboratory evaluation of the most promising routes in parallel enables rapid selection of the best route. We have established a robust process using internally developed screening platforms. In this critical process research stage, any concerns or potential problems will be identified, addressed and fully reported.
Deliverables: detailed synthesis report, reference sample.
Process Optimization
Objectives: provide a process-ready route.
Activities: Novalix has considerable experience of transferring processes to CDMOs, including GMP facilities.
Synthetic concepts are transformed into robust, reliable and cost-effective production processes that conform to industrial constraints. Scale-up and safety concerns are addressed. Flow chemistry is considered where appropriate.
Deliverables: detailed optimization report, representative sample (> 100 g).