We accelerate the DMTA cycle (Design/Make/Test/Analysis) using high-throughput synthesis and high-throughput experimentation.
Our approach is built on two complementary pillars: high-throughput experimentation (HTE) for rapid reaction optimization, and focused library synthesis to efficiently generate compounds supporting medicinal chemistry and drug discovery programs.
High-Throughput Experimentation: unlocking chemistry challenges
Objectives: Enable challenging transformations and optimize reactions to deliver target compounds at the required scale and quality while meeting critical project deadlines.
Our Platform for Accelerated Chemical Experimentation (PACE) supports both focused library synthesis and efficient production, contributing to efficient discovery processes.
Activities: PACE enables high-throughput chemical synthesis and reaction optimization to support rapid discovery.
PACE delivers high-throughput experimentation campaigns in 96-well plates, exploring reaction conditions using internal expertise, literature precedents, or AI-driven optimization strategies.
This structured high-throughput approach ensures reliability and reproducibility, supported by systematic high-throughput screening data analysis, providing a comprehensive solution to synthetic challenges.
Deliverables: A detailed report summarizing all experimental campaigns, including conversion data and a full account of the variables tested. Optimization is confirmed by an upscale, providing LCMS and NMR analyses of the isolated product.
Library Synthesis: rapid generation of new series
Objectives: Deliver focused compound libraries of 8–40 molecules per campaign, with 5–20 mg per compound, suitable for high-throughput screening services and medicinal chemistry programs.
Activities: Medicinal chemistry programs often require a rapid generation of focused libraries to quickly identify active compounds in a new series.
PACE enables the parallel high-throughput synthesis of 8–40 compounds per campaign, either from a final synthetic step or across two telescoped steps.
Reactions are executed, worked up, purified, and characterized in parallel, delivering the library within a few days.
These libraries can also include modern transformations, such as photocatalysis, broadening the accessible chemical space.
Deliverables: Standard Libraries of 8-40 compounds (5-20 mg each), LC-MS analysis for all compounds, with random NMR checks.
Transform your discovery timelines with high-throughput synthesis and expert chemistry support — contact our team.