We leverage high-throughput synthesis to accelerate the DMTA cycle (Design / Make / Test / Analysis) through high-throughput synthesis, built on two pillars:
- High-throughput experimentation (HTE) to rapidly optimize reactions and
- Focused library synthesis to efficiently generate compound libraries to support medicinal chemstry programs.
High-Throughput Experimentation: unlocking chemistry challenges
Objectives: Unlocking challenging synthetic transformations or optimizing reaction conditions for library synthesis.
Activities: Our Accelerated Chemistry Platform designs and executes HTE campaigns in 96-well plates, screening reaction conditions based on internal expertise, published literature or AI-driven optimization. This approach ensures high-throughput, reliability, and reproducibility, providing a comprehensive and systematic method for solving synthetic challenges.
Deliverables: A detailed report summarizing all experimental campaigns and corresponding conversion data.
Library Synthesis: rapid generation of new series
Objectives: Delivering focused compound libraries of 20-50 molecules (5-15 mg per compound).
Activities: Medicinal chemistry programs sometimes require the rapid generation of focused libraries to quickly confirm or rule out active compounds from a new series. Our Accelerated Chemistry Platform enables the parallel synthesis of 20-40 compounds, from a final synthetic step or from two telescoped steps. Reactions are executed, worked up, and purified in parallel, ensuring the library is produced within a few days. These libraries can also incorporate modern transformations such as photocatalysis, expanding the scope of accessible chemical space.
Deliverables: Libraries of 20-50 compounds (5-10 mg each), LC-MS analysis for all compounds, with random NMR checks.