Chemistry

Novalead: A better candidate

Our expert chemists thoughtfully apply our resources — including a proprietary DNA-encoded library — to refine and optimize the compound, perfecting the profile no matter how time-sensitive or complex the challenge.

A deep bench

Novalix has assembled all the disciplines, expertise and techniques that make a world-class chemistry research partner.

Organometallic and heterocyclic chemistry

Synthesis of focused libraries, standards and reference materials. Unique expertise in building sophisticated scaffolds with complex and diverse chemistry.

Process development

Our chemists design safe, shorter, replicable and scalable synthetic routes and processes, implementing them rapidly to reduce bottlenecks, capital investment and the cost of goods.

High-throughput synthesis

We deliver focused libraries within one week to accelerate the DMTA cycle (Design/Make/Test/Analysis) and enable efficient, robust reaction optimization through high-throughput chemistry, supporting drug discovery programs.

PROTACs

We offer the latest PROTAC (PROteolysis TArgeting Chimeras) synthetic technology to prepare Targeted Protein Degradation (TPD), using event-based target activity to redefine the principles of classical drug discovery.

Photo- and electro-chemistry

The Novalix chemistry platform provides both photochemistry, an increasingly viable synthetic strategy to produce active pharmaceutical ingredients (APIs), and electrochemistry, the scale and environmental benefit of which combines well with flow chemistry.

Flow chemistry

A powerful, safe innovative tool for process and discovery chemistry, now integrated with AI, that reduces the environmental footprint and enables hard-to-scale batch processes.

Analytical chemistry and purification

Empower your research with integrated analytical chemistry and purification solutions. From NMR and LC-MS to SFC and GC-MS, we deliver precision, quality control, and efficiency for small molecules, peptides, PROTACs, and complex compounds. 

DNA-Encoded Libraries

DNA-encoded libraries (DELs) represent a robust approach to hit identification and rapid lead generation. However, for too long, DNA-encoded library screening has been viewed primarily as a “number game”. Our DEL services deliver a different approach with a fully integrated DNA-encoded library CRO platform, designed to maximize hit quality and accelerate discovery timelines.  The approach combines advanced library design, rigorous quality control, AI-driven DEL data analysis, and drug-like confirmed hits, supporting pharma-proven results for challenging targets. 

Compound Management

Compound management plays a central role in the success of drug discovery research, where precise handling and traceability of samples is critical to ensure accuracy of results. With over 20 years of experience, we ensure the highest standards in sample handling and traceability.

Meet our experts

Some of the key leaders on the Novalix team in our Chemistry platform

Sophie Coupa

Senior Project Manager

More than 25 years of experience in organic synthesis in big pharma. Leading projects in photocatalysis developing our equipment and know-how.

Sylvain Guizzetti

Director Process and Flow

20 years of experience at Novalix as synthetic organic chemist. Developed and leads the flow and process chemistry platform.

Yannick Ligny

Senior Project Manager

More than 25 years of experience in organic synthesis in big pharma. Experienced in Parallel Medicinal Chemistry. Now head of the Accelerated Chemistry Platform.

Miguel Leonardo Martínez

Project Manager

Specialized in analytical services and purfication in industry. Coordinate teams, optimize analytical methods involving a wide range of techniques including DEL libraries.

Novalead at work