Chemistry

Novalead: A better candidate

Our expert chemists thoughtfully apply our resources — including a proprietary DNA-encoded library — to refine and purify the compound, perfecting the profile no matter how time-sensitive or complex the challenge.

A deep bench

Novalix has assembled all the disciplines, expertise and techniques that make a world-class chemistry research partner.

Organometallic and heterocyclic chemistry

Synthesis of focused libraries, standards and reference materials. Unique expertise in building sophisticated scaffolds with complex and diverse chemistry.

Process development

Our chemists design safe, shorter, replicable and scalable synthetic routes and processes, implementing them rapidly to reduce bottlenecks, capital investment and the cost of goods.

High-throughput synthesis

We use rapid synthesis to shorten the design-make-test cycle. We are equipped and trained to provide focused libraries in one week to validate a hypothesis quickly.

PROTACs

We offer the latest PROTAC (PROteolysis TArgeting Chimeras) technology to explore Targeted Protein Degradation (TPD), using event-based target activity to redefine the principles of classical drug discovery.

Photo- and electro-chemistry

The Novalix chemistry platform provides both photochemistry, an increasingly viable synthetic strategy to produce active pharmaceutical ingredients (APIs), and electrochemistry, the scale and environmental benefit of which combines well with flow chemistry.

Flow chemistry

A powerful, safe innovative tool for process and discovery chemistry, now integrated with AI, that reduces the environmental footprint and enables hard-to-scale batch processes.

DNA-encoded libraries synthesis

Our DNA-enabled libraries (DEL) are fully integrated and automated; a cost-effective approach to hit and lead generation that accesses a broad set of diverse chemotypes, and tracks all data from library synthesis through affinity selection.

Meet our experts

Some of the key leaders on the Novalix team in our Chemistry platform

Sophie Coupa

Senior Project Manager

More than 25 years of experience in organic synthesis in big pharma. Leading projects in photocatalysis developing our equipment and know-how.

Sébastien Richard

Senior scientist

18 years of experience in biotech and pharma. Experience in PROTACs.

Sylvain Guizzetti

Director Process and Flow

20 years of experience at Novalix as synthetic organic chemist. Developed and leads the flow and process chemistry platform.

Yannick Ligny

Senior Project Manager

More than 25 years of experience in organic synthesis in big pharma. Experienced in Parallel Medicinal Chemistry. Now head of the Accelerated Chemistry Platform.

Novalead at work