Strong expertise in solution NMR and access to ultra-high field instruments for fragment-based drug discovery and structural elucidation.
At Novalix, we apply the power of cutting-edge NMR technologies to accelerate early-stage drug discovery. Our integrated platform offers both fragment screening and 3D solution structure determination, enabling a more accurate transition from hit identification to structural insight. Whether you’re exploring ligand interactions through fragment screening or seeking atomic-level resolution of your soluble protein target, state-of-the-art Bruker instruments—ranging from 600 MHz to 1 GHz—combined with automated workflows and AI-driven analysis, ensure precision, speed, and flexibility tailored to your project’s needs.
With our extensive experience, we provide customized NMR solutions encompassing:
Fragment screening
Novalix offers both ligand-observed and protein-observed methods tailored to your target’s specific needs. We access the latest Bruker NMR instruments equipped with cryogenic-cooled probes for sensitivity and automatic sample changers for high-throughput measurements. You can choose to screen our internal fragment library, your own preferred library, or any commercial collection. With the help of our compound management platform, we can process any fragment collection into the plate format and stock concentration required for any biophysical method.
3D solution structure by NMR
Novalix operates ultra-high-field Bruker NMR instruments alongside the AI-based software ARTINA, enabling rapid and cost-effective assignment and determination of protein structures. From a high-quality NMR spectral set to an atomic-resolution 3D protein structure in just one day, these accelerated timelines position NMR as a compelling and complementary method to X-ray crystallography and cryogenic electron microscopy.
*Klukowski, P., Riek, R. & Güntert, P. Rapid protein assignments and structures from raw NMR spectra with the deep learning technique ARTINA (2022). Nature Communications 13, 6151.
Want to explore how our advanced NMR platform can support your discovery projects? Contact us.