Cryo-EM developed to be complementary to protein X-ray crystallography, suitable for antibodies, difficult and ternary protein structures, as well as membrane proteins.
Our cryo-EM services has been meticulously refined by our expert team to provide comprehensive, high-quality protein structure determination solutions, from gene to validated structure.
This achievement through a unique combination of integrated technologies, deep scientific expertise, and strategic partnerships. Our collaboration with the Max Planck Institute provides access to specialized cryo-EM knowledge and exclusive next-generation image-refining software, ensuring speed, accuracy, and reliability throughout the entire process.
Our molecular dynamics capabilities and drug discovery insight further validate binding sites, laying a solid foundation for your discovery program. It’s this synergy that brings confidence to your structural biology journey.
Protein Science
- Efficient protein expression in relevant cellular systems
- Expertice in both soluble and membrane proteins
- Advanced purification techniques and a broad range of stabilization methodologies
Feasibility Study
- High-throughput grid preparation and rigorous grid screening
- In-house Glacios microscope for immediate evaluation
Robust 2D classification for rapid quality assessment
Data Collection and Processing
- State-of-the-art image capture using Falcon4i detectors
- High-resolution data processing leveraging our in-house HPC cluster equipped with 20 NVIDIA GPUs
- Quick access to Titan Krios microscope for demanding targets
Structure Delivery
- Expert model building and refinement
- Comprehensive structural analysis
- Validation enhanced by molecular dynamics simulations
- Detailed and insightful reporting
High-Resolution Cryo-EM Structure of TGR5 for Structure-Based Drug Design (SBDD)
We successfully determined the high-resolution cryo-EM structure of the Gs-coupled receptor TGR5 bound to the small molecule agonist P395, achieving an impressive resolution of 2.5 Å—surpassing previously published structures (e.g., PDB: 7CFM). This result highlights our advanced capabilities in resolving fine molecular details critical for understanding receptor-ligand interactions.
This achievement demonstrates the effectiveness and quality of our cryo-EM services, providing a strong foundation for structure-based drug design (SBDD). Our team consistently delivers reliable, publication-ready structures that accelerate drug discovery.
From gene to validated 3D structure — contact us to see how our cryo-EM expertise can advance your research.