NovAliX will take part in the second edition of the EMBL Industry Workshop in Heidelberg, Germany.
This workshop aims to bring the academic and industrial cryo-EM communities together to evaluate how the use of cryo-EM has developed 10 years on from the “cryo-EM resolution revolution”. The meeting will showcase high-quality research in academia and industry. It will also provide updates on recent and ongoing methodological developments.
Dr Denis Zeyer, NovAliX CEO, will hold a lecture entitled “From implementing cryo-EM to effectively supporting structure-based drug design: a 8-year journey at NovAliX” on January 29, 2024.
Cryo-Electron Microscopy (cryo-EM) is now a key technology in the field of structural biology, offering sufficient resolution for its application in structure-based drug design. This encompasses both small molecule therapeutics and biologics development. Ten years ago, the publication of the first high-resolution structures sparked debate about its potential impact and adoption by the pharmaceutical industry. Today, cryo-EM has become an indispensable complement to X-ray crystallography, particularly for acquiring structures of difficult targets such as membrane proteins and multi-protein complexes that are resistant to crystallization.
This presentation will guide you through a decade-long evolution, from the establishment of a cryo-EM facility at Novalix. We’ll recount the crucial moments in the capture of high-resolution structures, and look at the integral role cryo-EM currently plays in our drug discovery efforts, while providing a glimpse of its potential future applications.