Join NovAliX at the 4th Alpine Winter Conference on Medicinal and Synthetic Chemistry 2024! Our team of scientific and business development experts will be available on our booth No.3 in St Anton, Austria, from January 28 to February 1, 2024.
Integrating single-particle Cryogenic-Electron Microscopy and Hydrogen/Deuterium eXchange Mass Spectrometry to elucidate the structure and dynamics of G-Protein-Coupled Receptors (GPCRs)
Do not miss the poster session on January 29!
Dr Gilbert Bey, Head of Membrane Proteins, will share some recent work from the NovAliX Structural Biology and Biophysics departments demonstrating the powerful integrated Cryo-EM and HDX-MS workflow.
The TGR 5 structure has been successfully elucidated at an exceptionally high resolution, revealing the binding site of the ligand P 395. Moreover, we managed to resolve a flexible domain that is visible for the very first time. This observation aligns with the high quality HDX MS data we have gathered. Collectively, these data provide invaluable insights into the dynamics of TGR 5 and can potentially be extrapolated to shed light on various GPCRs and, more broadly, other proteins. NovAliX has played a pivotal role in producing all these proteins, generating quantities and qualities compatible with our research methods.
About Alpine Winter Conference
Organized by LD Organisation, this EFMC sponsored event will feature cutting edge synthetic and medicinal chemistry. In addition, it will highlight the latest developments in innovative technologies in drug discovery.
Some of the conference topics will include:
- Antiviral drug discovery
- Cryo-EM: Applications for structure-based drug discovery
- Recent developments in synthetic methodologies and their impact
Let’s get in touch on our booth No 3
Interested in learning more on both stand-alone and integrated drug discovery projects, from target validation to the selection of the final clinical candidate?
Meet our seasoned team at Alpine Winter Conference 2024 on stand No 3, we will be more than happy to set up a collaboration with you!