By this new transformation in organic synthesis, the Prof. Leonori’s group, in collaboration with AstraZeneca UK, showed that copper catalysis enables the coupling between an alkyl radical (generated from the corresponding alkyl iodide) and aryl amines, amides, carbamates, etc… This new synthesis tool is of particular interest to secondary alkyl halides, which usually suffer from competitive E2-elimination when engaged in traditional SN2 conditions.
Górski, B., Barthelemy, AL., Douglas, J.J. et al. Copper-catalysed amination of alkyl iodides enabled by halogen-atom transfer. Nat Catal4, 623–630 (2021). https://doi.org/10.1038/s41929-021-00652-8
Published: 12, July, 2021
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