Silas P. Cook and co-worker from Indiana University reported recently a two-step deoxytrifluoromethylation of aliphatic alcohols. Their transformation proceeds via the formation of  O-alkyl thiocarbonates, followed by a blue led-driven copper-mediated (Grushin’s reagent : bpyCu(CF3)3) trifluoromethylation. The reaction provides broad functional group tolerance (e.g., alkyne, alkene, phenol, free alcohol, electron-rich and -deficient arenes). A nice extra tool for new potential CF3-containing synthons.

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