Cryo-EM has displayed its potential in an article by Wrapp and Wang et al. recently published on Science to tackle the current outbreak of coronavirus disease caused by the virus 2019-nCoV.
The structure of glycosylated spike (S) protein of 2019-nCoV was solved by cryo-EM at 3.5Å. The S protein plays a key role in coronavirus’ access to the host cell, with which the virus could fuse its membrane to the cell membrane of the host. We are very impressed that this structure is solved by cryo-EM within two months and we hope the elucidation of the protein structure could facilitate the development of medical countermeasure development.