After its first report on the C-H functionalization by thianthrenation published in Nature 6 months ago (https://lnkd.in/djfF6v9), Ritter’s research group strikes again and expands the scope of this elegant and versatile methodology for the formation of C-N bonds. Using either palladium catalysis or a photoredox catalyst, the authors have been able to functionalize aryl C-H bonds with a wide range of N-nucleophiles (such as amines, amides, carbamates, and azoles among others) via the intermediacy of aryl sulfonium salts obtained by site-selective C-H thianthrenation. Complementary to this work, the group has also just reported the use of the methodology for the construction of C-O bonds (https://lnkd.in/d7Cvgz2). Overall, this is a very powerful new tool for synthetic chemists !

https://pubs.acs.org/doi/10.1021/jacs.9b07323