Abigail G. Doyle et al. have developed a mild, photocatalytic method for diverse site-selective C (sp3)−H functionalisation:

  • Sulfonyl)amidation, azolation, hydroxylation, esterification, etherification, and halogenation.
  • Low-cost nucleophiles as coupling partners.
  • A novel organic photocatalyst used: CF3-4-CzIPN.
  • HAT-ORPC (oxidative radical-polar crossover) mechanism.

Publication Authors: 

Madeline E. Ruos,  R. Garrison Kinney,  Oliver T. Ring, and  Abigail G. Doyle*. J. Am. Chem. Soc. 2023, 145, 33, 18487–18496). https://doi.org/10.1021/jacs.3c04912

Published: August 11, 2023

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