NovAliX at Organic Process Research & Development Conference

NovAliX was present at 50th Organic Process Research & Development Conference (OPR&D) in Barcelona, Spain, from 2nd to 4th October 2023.
Highlighting cutting-edge scientific technologies in process chemistry, this conference facilitates networking between chemists, chemical engineers in industry and heads of departments.

Organized by Scientific Update Ltd, Organic Process Research & Development Conference 2023 celebrated its 50th anniversary.

Conferences on process development dealt with scientific content:

• 2nd generation processes in Osimertinib
• challenges for process chemistry in the 21st Century
• development of a process to manufacture Psilocybin
• case studies
• modelling a continuous process in heterogeneous mixture across a series of CTRs
• digitizing process development at Boehringer Ingelheim
• and much more…

Conclusions and remarks

Back from Organic Process Research & Development Conference after a truly great week, we are very happy to share our thoughts and remarks  below.

• In the first day session, Dr Kai Rossen (OPRD Editor-in-Chief of OPRD, Germany) gave an extraordinary lecture on ‘Challenges for Process Chemistry in the 21^st Century’. He highlighted the importance of process chemist awareness of environmental impact on chemical production (including raw materials burden evaluation). His point was illustrated with meaningful examples: how innovative thinking can provide solutions to improve the process footprints, how green metrics should be considered with care…
• Then we also noted the talk from Oliver Ring (ASTRA-ZENECA, Sweden), enthralled us with his talk on ‘Total Synthesis of AZD5991 from a process chemistry perspective’. He presented a comprehensive route scouting review towards the scale-up synthesis of a highly challenging macrocycle containing 4 (hetero)aromatic rings. In addition to modern synthetic methods, highly original old-fashioned chemistry for pyrazole ring formation and selective naphthalene functionalization resulted in an impressive reduction in synthesis length and increased efficiency.
• Last but not least Dr Jamie McCabe Dunn from MERCK, USA, held a session dealing with the ‘Development of a process towards MK-7845 as an investigational treatment for Covid-19’.  The potential of a bunch of interesting transformations such as Claisen condensation under flow condition or an original diastereoselective Ugi reaction to access a chiral bicyclic proline was harnessed to afford a scalable synthesis of the requested API despite considerable time pressure.

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