RICT 2025 Conference on Medicinal Chemistry

Meet Novalix at RICT 2025 in Orléans, France, from July 2 to 4. The 59th International Conference on Medicinal Chemistry is organized by The French Medicinal Chemistry Society (Société de Chimie Thérapeutique – SCT).

The conference will focus on “Drug Discovery and Selection” with a range of scientific topics, including 18 plenary lectures and 6 short lectures. 2 plenary lectures will also be delivered by the recipients of awards:

• Prof. Anna K.H. Hirsch, from Helmholtz Institute for Pharmaceutical Research Saarland (Germany)

• Dr Julien Rey, from Novartis (Switzerland)
  

Discover our scientific posters

We are proud to announce that Novalix scientific team will present two posters at RICT 2025 on July 3rd at 1:40 p.m.

• Identification of a submicromolar BRD4 PROTAC degrader from a moderately potent DEL Hit: harnessing the synergy of DEL and PROTAC technologies (ref. P132)
  presentation by Jacques Huck, Research Fellow, Project Leader Drug Discovery
  
  Abstract:
  In this study, we present the identification of a BRD4 PROTAC degrader with submicromolar degradation potency, derived from a moderately potent hit identified through a DNA-encoded library (DEL) screen using our NovaDEL platform. Remarkably, this degrader was obtained without any further optimization of the initial Hit selected from the DEL screen, showcasing its inherent efficacy. While the theoretical feasibility of degrading proteins using binders with moderate potency is recognized, there are few documented instances in the literature of successful protein degradation from micromolar binders. Our findings underscore the acknowledged yet underreported potential of PROTAC technology to achieve efficient protein degradation even from less potent initial hits. […]
  Discover more on-site!
  

• Identification and characterization of small molecules inhibiting RNA targets: miRNA targeting platform (ref. P142)
  presentation by Sonia Dupont, Director in vitro Biology and Biomarkers
  
  Abstract:
  Targeting RNAs with small molecules is a promising modality for oncology, cardiovascular diseases and CNS disorders. Dys-regulation of microRNAs playing key roles in the genesis of the different diseases have attracted growing interest to tackle unmet medical needs.  A robust flowchart has been implemented to identify and optimize new efficient inhibitors of microRNAs. […]
  Discover more on-site!
  

More details about RICT 2025

The sessions will include some topics such as:

• Next generation anti-infective agents
• New avenues in chemistry for drug discovery
• Recent advances in targeting RNA with small molecules
• Molecular modeling and machine learning for drug design
• Neurodegenerative diseases
• Biophysics and target validation in drug discovery

Visit us at our booth No. 29

Come and discuss your scientific projects with our Business Development and scientific team at our booth No. 29 at RICT 2025: