Meet Novalix Key Opinion Leaders at Drug Discovery Chemistry 2025, a conference dedicated to medicinal and biophysical chemists working in pharma, biotech, and academia. Organized by Cambridge Healthtech Institute (CHI), this 20th edition will focus on discovery and optimization challenges of small molecule drug candidates.
“Identification of a submicromolar BRD4 PROTAC degrader from a moderately potent DEL Hit: harnessing the synergy of DEL and PROTAC technologies”
Do not miss our poster presentation: Poster No. B27, Session B on Wednesday afternoon, April 16 and Thursday, April 17.
Laurent Saniere, SVP Drug Discovery, will present how a DEL screening of 30 million compounds led to micromolar hits, which were rapidly optimized into a submicromolar PROTAC degrader using the Novalix PROTAC toolbox, showcasing the potential of moderately potent binders for effective protein degradation and drug discovery.
Introduction: DEL technology has established itself as a method of choice for binder identification across a broad variety of protein targets. Novalix adopted several years ago a differentiating strategy focused on producing druglike and diverse hits with ADME-proof properties. This diversity and drug-likeness are ensured through stringent selection of building blocks (BBs) and careful design of DEL libraries. Novalix has built and continuously expanded a DEL platform, which now comprises over 250 million compounds from 12 DEL libraries. […]
More details on Drug Discovery Chemistry
Both in-person and online, the event offers plenary keynote sessions and a plenary panel discussion featuring insights from venture capitalists. Some of the topics will include:
- Degraders and molecular glues: beyond oncology
- Covalent and induced proximity-based therapies
- Generative AI and predictive modeling
- Drug discovery in women’s health
- RNA-modulating small molecule drugs
- Fragment-based drug discovery
- AI/ML for early drug discovery
- GLP1 and oral peptides
- Protein-protein interactions
- DNA-Encoded libraries
Event location:
Hilton Bayfront, San Diego, CA
Meet us at our booth No. 314
If you are also attending, visit us at our booth No. 314! Set a meeting and catch up:
Event
Visit websiteDate
From
Apr 14, 2025
to
Apr 17, 2025
Location
San Diego, CA, USA
Attendees
Frank Moffatt
Senior Director of Business Development
Laurent Saniere, PhD
SVP Drug Discovery
Felix von Haniel, MBA
SVP Business Development and Marketing