Target Druggability

Druggability assessment using extensive structural biology expertise

NovAliX offers two complementary approaches:

  • In silico

Using 3D structures or homology models, we can identify accessible pockets and calculate their physicochemical and geometric properties. Chemoinformatic tools, such as SeeSAR (BioSolveIT), enable us to perform virtual screening on these cavities, using libraries which contain hundreds of millions of purchasable compounds.

  • Experimental approach

Binding assessment of selected small libraries (target focused or fragment libraries on the target of interest using our biophysical platforms.

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