Overview of Screening Methodologies
| Method | Strengths | Limitations | Typical Use Cases |
| DNA-Encoded Libraries (DEL) | Ultra-large chemical space; efficient hit identification; integrated QC | Requires specialised library design; artefact risk | Challenging targets; early-stage discovery |
| High-Throughput Screening (HTS) | Established workflows; broad assay compatibility | Limited library diversity; higher resource requirements | Lead identification; routine screening |
| Fragment Screening | High-resolution biophysical data; efficient SAR | Small chemical space; lower throughput | Lead optimisation; structure-guided design |
Summary Takeaway
Each screening method offers distinct advantages and limitations. Novalix’s NovaDEL platform stands out for its integrated, quality-driven approach, supported by cheminformatics and AI to maximise hit reliability. Selection depends on target characteristics, project stage, and required throughput.
Contact Novalix to discuss optimal screening strategies for your targets.