Native Mass Spectrometry

Insight into drug Interactions

Binding
  • Affinity
  • Stoichiometry
  • Competition versus allosteric and orthosteric ligands
  • Cooperativity
  • Stability
Targets characterization
  • Intact mass
  • Purity/Homogeneity
  • Post-translational modifications
  • Detection of fortuitous ligands
  • Oligomerization state and molecular dynamics
Biologics and biosimilars
  • Fab-arm exchange (FAE)
  • Quantity glycoforms
  • Detect the lysine clipping
  • Measure the drug-to-antibody ratio (DAR) for antibody drug conjugates (ADC).

Over the last 20 years, NovAliX has routinely used native MS. Our extensive track record of complex studies includes proteins, biologics, nucleic acids, lipids and sugars.

This fast and reliable technique can provide both qualitative and quantitative information.

All these data provide key elements to understand drug interaction modes. The NovAliX MS platform is also designed to support screening, including fragment libraries

Native MS: an ‘ESI’ way to support structure- and fragment-based drug discovery.

Find more information in the chapter on mass spectroscopy in the following book from Jean Paul Renaud (cofounder and President & Chief Scientific Officer at Urania Therapeutics also cofounder of NovAliX):

Structural Biology in Drug Discovery: Methods, Techniques, and Practices

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