We are proud to announce the successful thesis defense of Dr Gwendoline Lozachmeur after three years of research in pharmacology.
“Towards the development of a spatial epigenomics landscaping strategy for studying tissue architecture”
Her thesis was carried out in collaboration between Novalix and SysFate Team at CEA Genoscope through a CIFRE grant.
Supervised by Dr Anne Gigout, Associate Director in vitro Biology, Biomarkers, Biobank at Novalix, this research aimed to explore new strategies to enhance process efficiency, reducing both costs and timeframes.
Innovative research targeting chronic inflammatory diseases
Chronic inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) continue to affect millions, with no curative treatments currently available. A key obstacle lies in the difficulty of identifying effective therapeutic targets due to the complexity and variability of these diseases.
Gwendoline’s thesis work pioneers a spatial multi-omics approach, a cutting-edge method that combines transcriptomic and epigenomic analyses to study inflammation within the tissue’s spatial architecture.
Using innovative protocols developed by her team, Gwendoline maps inflammatory cell infiltration in disease models such as MDR1a-/- mice (for IBD) and CIA mice (for RA). Her work is especially impactful in tissues where RNA is degraded, such as bone and cartilage, thanks to a modified Cut & Tag protocol that enables epigenomic analysis even in FFPE-preserved samples.
By revealing how genes are expressed or repressed in specific tissue regions, Gwendoline’s research opens new avenues for identifying precise therapeutic targets, laying the groundwork for curative and even preventive treatments for chronic inflammatory diseases.
We extend our warmest congratulations to Dr Gwendoline Lozachmeur and wish her a fulfilling career in science research.